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MYP_060477
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Basic Information
Ranacyclin-B-RN1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
19 amino acids
C96H145N25O24S2
Standard
Sequence
SALVGCWTKSYPPKPCFGR
Physicochemical Analysis
2097.46 Da
9.38
2.44
2.20
0.1283
-0.25
0.29
0.05
18.25
41.05
0.1579
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
771.40
-6.71
29.0
29.0
60.0
147.0
7.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0021514 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Ranacyclin
127021
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus ATCC 25923
6 μM
MIC
PMID21927839 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21927839/
RECORD: Rec_0152851 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Nigroain
127021
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
6-16
Bio-Activity Profile
Antimicrobial Antibacterial
PaperY. Ma et al. / Genomics 95 (2010) 66-71. Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0264831 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0311678 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
127021
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
6-16
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
6 μM
MIC
PaperBi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins
RECORD: Rec_0318481 VERIFIED: NO
Provenance & Taxonomy
Rana nigrovittata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
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