Peptide Database

Peptide NamePanusin (Defensin-like peptide 7, PaD7)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC183H270N54O57S6

DescriptionStandard

        SYVGDCGSNGGSCVSSYCPYGNRLNYFCPLGRTCCRHAYV
    

Molecular Weight4330.82 Da

Isoelectric Point (pI)8.28

Net Charge (pH 7.0)1.48

Net Charge (pH 7.4) 1.13

Charge Density (pH 7.0) 0.0371

GRAVY Index-0.19

Hydrophobic Moment 0.64

Boman Index0.03

Instability Index28.23

Aliphatic Index 43.75

Aromaticity 0.1500

Extinction Coeff. Reduced 7450.00

Extinction Coeff. Oxidized 7825.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1784.12

LogP -24.05

H-bond Donors 70.0

H-bond Acceptors 66.0

Rotatable Bonds 130.0

Heavy Atoms 300.0

Ring Count 9.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0122107 VERIFIED: YES

Provenance & Taxonomy

OrganismPanulirus argus [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide6-28, 13-34, 18-35

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic

RECORD: Rec_0131680 VERIFIED: YES

Provenance & Taxonomy

OrganismPanulirus argus [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide6-28, 13-34, 18-35

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli ATCC 25922

Activity4.8 μM

MethodMIC

RECORD: Rec_0187501 VERIFIED: YES

Provenance & Taxonomy

OrganismPanulirus argus [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide6-28, 13-34, 18-35

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetIt shows no hemolytic effect on human red blood cells

RECORD: Rec_0423181 VERIFIED: YES

Provenance & Taxonomy

OrganismPanulirus argus [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide6-28, 13-34, 18-35

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus ATCC 29737

Activity3.46 μM

MethodMIC