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MYP_060031
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Basic Information
Bombolitin III
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
17 amino acids
C87H156N22O20S
Standard
Sequence
IKIMDILAKLGKVLAHV
Physicochemical Analysis
1862.37 Da
9.70
1.85
1.59
0.1086
1.18
0.70
0.36
-9.22
183.53
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
672.96
-1.00
23.0
24.0
66.0
130.0
1.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0040788 VERIFIED: YES
Provenance & Taxonomy
American common bumblebee [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Toxicity
the peptide is highly hemolytic to pig RBC erythrocyte
2.8 μg/mL
ED50
PaperBombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus.
RECORD: Rec_0095503 VERIFIED: NO
Provenance & Taxonomy
Megabombus pennsylvanicus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone
RECORD: Rec_0164758 VERIFIED: YES
Provenance & Taxonomy
Megabombus pennsylvanicus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Cytotoxic
PaperPubMed PMID: 2578459 PMID2578459 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2578459/
RECORD: Rec_0249771 VERIFIED: YES
Provenance & Taxonomy
Megabombus pennsylvanicus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Cytotoxic Hemolytic
guinea pig erythrocytes
PaperPubMed PMID: 2578459 PMID2578459 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2578459/
RECORD: Rec_0276813 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
PaperArgiolas A., Pisano J. J.. Bombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus. J. Biol. Chem., 260, 1437-1444, 1985.
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