Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length460 amino acids

Chemical FormulaC2322H3690N594O643S17

DescriptionStandard

        KGEKMLKTWYSFLLCWLSLRLEANPGLKVRITQKGLDYGRRIGMELLKQAILKETFPSWSGQESFSVVKVNYVISRLRINAVDFPETSASFIPGTGISLSVAHASAMISADWRMNTWLLKNQGGITVSISGLFIAVIFKVSRDSTGHLSMLLHNCQLSINSVKVNLNGGSSWIHSFLSGYLEKPIHTKLDKNLCLYIKYKIQMMDAELRKHKVLSQIDAFAQIDYSLVSSPAVFKSHINLDLKGTVYPVGNHTDPPFVPALFALPNQGDSMLYLGVSSYFLKSASLAYYRAGAFNITISKELATTFNLNTALFKDFVPEIALSYVTACPVLLKLMATSPPAVSLNADGCILQITSCVEVFAVLPNSTTQYIFTGNLTASTRANLTITKQKLIISLLLKRLQFSLLHSTPGFSEMSLVKNFLSYALRTAVIPVINDKLGKGFPLLNLAHTTLTGPVIKMNQ
    

Molecular Weight50760.83 Da

Isoelectric Point (pI)9.56

Net Charge (pH 7.0)18.58

Net Charge (pH 7.4) 17.68

Charge Density (pH 7.0) 0.0404

GRAVY Index0.24

Hydrophobic Moment 0.72

Boman Index0.17

Instability Index28.60

Aliphatic Index 107.26

Aromaticity 0.0957

Extinction Coeff. Reduced 55350.00

Extinction Coeff. Oxidized 55725.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0113397 VERIFIED: NO

Provenance & Taxonomy

OrganismPelecanus crispus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria