Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length485 amino acids

Chemical FormulaC2385H3767N613O701S18

DescriptionStandard

        MLSLLILLLNLTNHAFGQNPAIKAILTNKGLQYGSHIGADWMQEKIGSVIIPDVRGGVDIGIGTVHYVLDRISVSGCDVPEPSVEFFEGVGLKAVISGLSISMSGNWHTTFGIITDGGSFDLAVFNVDVTSVVQIGSDLSGHISISSENCDARVGEASINFHGGASLIFQPFVSLFHNRIKAIIEERICPVVEERVTDLERHLSEMQVSFKVNSALVLDVPLTNSPLVDSISLGLDLKGEFYSVQSHTDPPFKAEPFNLPEDKGHMLSLGLSEFTVNSASYAYFSAGLLQAQINDSMIPKTSPFRLNTTSFGPLIPQLPKLFPNMLMELQVYARDAPMFSFQADKVTLEFPGAVKAFAIQPNASRTPLFKLNVDSIFSGMIRISEEKVKGMMELSNFTLTLASSEVGTFQTAALENFMKLGMKISVLAKLNAKLKEGIVLPTMHHIHLVNPVLKIQQGFVSIASDLDVKSGERESISEGIYPYRL
    

Molecular Weight52821.28 Da

Isoelectric Point (pI)5.48

Net Charge (pH 7.0)-12.33

Net Charge (pH 7.4) -13.35

Charge Density (pH 7.0) -0.0254

GRAVY Index0.18

Hydrophobic Moment 0.64

Boman Index0.18

Instability Index31.72

Aliphatic Index 102.47

Aromaticity 0.0804

Extinction Coeff. Reduced 22920.00

Extinction Coeff. Oxidized 23045.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0381658 VERIFIED: NO

Provenance & Taxonomy

OrganismSalmo salar [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence