Peptide Database

Peptide NameSLAY-screened peptide P127

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC90H121N21O20

DescriptionStandard

        PHGHSFHVYISLLFY
    

Molecular Weight1817.05 Da

Isoelectric Point (pI)7.41

Net Charge (pH 7.0)0.22

Net Charge (pH 7.4) 0.01

Charge Density (pH 7.0) 0.0145

GRAVY Index0.41

Hydrophobic Moment 0.26

Boman Index0.43

Instability Index19.13

Aliphatic Index 97.33

Aromaticity 0.2667

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 623.69

LogP -1.70

H-bond Donors 23.0

H-bond Acceptors 23.0

Rotatable Bonds 52.0

Heavy Atoms 131.0

Ring Count 8.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0299546 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/