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MYP_059791
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Basic Information
Drosocin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
19 amino acids
C98H160N34O24
Standard
Sequence
GKPRPYSPRPTSHPRPIRV
Physicochemical Analysis
2198.53 Da
12.00
4.85
4.59
0.2550
-1.58
0.33
-0.45
41.15
35.79
0.0526
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
917.60
-10.04
32.0
30.0
61.0
156.0
8.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0290181 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Drosocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Multifunction
CEM-SS
>45.5 μM
IC50
PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
RECORD: Rec_0296004 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0318683 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli BL21
117
MIC
PMID26448548 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26448548/
RECORD: Rec_0336689 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://patents.google.com/patent/US5466671A/en PatentUS 5466671 A
RECORD: Rec_0337571 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperMcManus A.M., Otvos L. Jr., Hoffmann R., Craik D.J.;. "Conformational studies by NMR of the antimicrobial peptide, drosocin, and its non-glycosylated derivative: effects of glycosylation on solution conformation."; Biochemistry 38:705-714. Evidence URLhttps://www.uniprot.org/uniprotkb/DROS_DROME/entry
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