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MYP_059791
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Basic Information
Drosocin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
19 amino acids
C98H160N34O24
Standard
Sequence
GKPRPYSPRPTSHPRPIRV
Physicochemical Analysis
2198.53 Da
12.00
4.85
4.59
0.2550
-1.58
0.33
-0.45
41.15
35.79
0.0526
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
917.60
-10.04
32.0
30.0
61.0
156.0
8.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0254225 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Drosocin
7227
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Antimicrobial Antiparasitic
P. indica and R. solani
<20 μM
IC50
PaperA novel inducible antibacterial peptide of Drosophila carries an O-glycosylated substitution
RECORD: Rec_0255274 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Rat erythrocytes
100 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/21968924/ PMID21968924 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21968924/
RECORD: Rec_0267817 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli D31
0.5-1.0 μM
MIC
PMID7588819 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7588819/
RECORD: Rec_0280499 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
*=α-GalNAc
Bio-Activity Profile
Antimicrobial Toxic Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0283627 VERIFIED: YES
Provenance & Taxonomy
Drosophila sechellia [Animal]
Drosocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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