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MYP_059656
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-Retrovirus ▸ Anti-HTLV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
22 amino acids
C111H188N34O34
Standard
Sequence
LNITNSHVSILQERPPLENRVL
Physicochemical Analysis
2542.89 Da
6.76
-0.15
-0.40
-0.0067
-0.28
0.38
-0.05
72.52
132.73
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1116.97
-11.34
37.0
35.0
83.0
179.0
3.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037520 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0164864 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/
RECORD: Rec_0209736 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HTLV Fusion inhibition
HTLV | T cell; 293T cells
5.8 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperBasic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry. | Lamb D, Mirsaliotis A, Kelly SM, Brighty DW. | J Biol Chem. 2009 Mar 6;284(10):6575-84. | DOI:10.1074/jbc.M806725200 | PMID:19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/
RECORD: Rec_0395547 VERIFIED: YES
Provenance & Taxonomy
Human T-lymphotropic virus 1 [Virus]
Virus-derived peptide
11908;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Human T-cell leukaemia virus 1 (Virus entry); 293T
5.8 μM
Luciferase assay
PaperBasic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry. | Lamb D, Mirsaliotis A, Kelly SM, Brighty DW. | J Biol Chem. 2009 | PMID:19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/
RECORD: Rec_0419978 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Human T cell leukemia virus type 1(HTLV-1):inhibition of mambrane fusion in 293T cells
5.8 μM
IC50
PaperPubMed PMID: 19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/