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MYP_059626
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Anti-breast cancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
7 amino acids
C43H64N10O12
Standard
Sequence
RYLGYLE
Physicochemical Analysis
913.03 Da
6.22
-0.23
-0.44
-0.0334
-0.49
0.53
-0.02
-14.33
111.43
0.2857
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
377.58
-0.94
14.0
12.0
28.0
65.0
2.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076077 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Anticancer Cytotoxic Anti-breast cancer Cell-proliferative
decreased breastcancer cell proliferation
Cell proliferation assay
PaperAntiproliferative and receptor binding properties of α- and β-casomorphins in the T47D human breast cancer cell line | Hatzoglou, A. et al. | DOI: 10.1016/0014-2999(96)00339-1 Evidence URLhttps://www.uniprot.org/uniprotkb/P02662/entry
RECORD: Rec_0174074 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
acts as an opiate
1.2 μM
IC50
RECORD: Rec_0180471 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant
PaperAmigo L., Mart¨ªnez-Maqueda D., Hern¨¢ndez-Ledesma B.. In silico and in vitro analysis of multifunctionality of animal food-derived peptides. Foods, 9, 991, 2020.
RECORD: Rec_0193565 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Casomorphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperHatzoglou A., Bakogeorgou E., Hatzoglou C., Martin P.-M., Castanas E.. Antiproliferative and receptor binding properties of alpha- and beta-casomorphins in the T47D human breast cancer cell line. Eur. J. Pharmacol., 310, 217-223, 1996.
RECORD: Rec_0269897 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Casomorphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Agonist
opioid receptor
PaperLoukas S., Varoucha D., Zioudrou C., Streaty R. A., Klee W. A.. Opioid activities and structures of alpha-casein-derived exorphins. Biochemistry, 22, 4567-4573, 1983.
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