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MYP_059591
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Basic Information
P59, GBV-C E2 (175-192)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
18 amino acids
C93H146N28O24S
Standard
Sequence
RFPFHRCGAGPKLTKDLE
Physicochemical Analysis
2072.39 Da
9.31
1.84
1.57
0.1025
-0.79
0.43
-0.20
21.41
48.89
0.1111
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
839.79
-7.09
30.0
28.0
66.0
146.0
5.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0071240 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1
PMID20718496 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20718496/
RECORD: Rec_0073520 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 | gp41-induced cell; -cell; CEM-174 cells
529.6 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperEffect of synthetic peptides belonging to E2 envelope protein of GB virus C on human immunodeficiency virus type 1 infection. | Herrera E, Tenckhoff S, Gómara MJ, Galatola R, Bleda MJ, Gil C, Ercilla G, Gatell JM, Tillmann HL, Haro I. | J Med Chem. 2010 Aug 26;53(16):6054-63. | DOI:10.1021/jm100452c | PMID:20718496 PMID20718496 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20718496/
RECORD: Rec_0111217 VERIFIED: YES
Provenance & Taxonomy
GB virus C [Virus]
54290
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
530 μM
IC50
PaperStudy of the inhibition capacity of an 18-mer peptide domain of GBV-C virus on gp41-FP HIV-1 activity. PMID21377446 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21377446/
RECORD: Rec_0137657 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PMID20718496 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20718496/
RECORD: Rec_0163853 VERIFIED: YES
Provenance & Taxonomy
GB virus C [Virus]
54290
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
CEM-174
60 %
Inhibition
PaperEffect of synthetic peptides belonging to E2 envelope protein of GB virus C on human immunodeficiency virus type 1 infection. PMID20718496 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20718496/
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