Peptide Database

Peptide NameAlemtuzumab

Function Ontology

Anticancer

Standard StatusStandard

Sequence Length240 amino acids

Chemical FormulaC1138H1770N302O352S9

DescriptionStandard

        QVQLQESGPGLVRPSQTLSLTCTVSGFTFTDFYMNWVRQPPGRGLEWIGFIRDKAKGYTTEYNPSVKGRVTMLVDTSKNQFSLRLSSVTAADTAVYYCAREGHTAAPFDYWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG
    

Molecular Weight25602.62 Da

Isoelectric Point (pI)8.81

Net Charge (pH 7.0)5.05

Net Charge (pH 7.4) 4.49

Charge Density (pH 7.0) 0.0210

GRAVY Index-0.19

Hydrophobic Moment 0.58

Boman Index0.08

Instability Index42.01

Aliphatic Index 69.38

Aromaticity 0.0917

Extinction Coeff. Reduced 35410.00

Extinction Coeff. Oxidized 35785.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0277212 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Mus musculus [Animal]; Cricetulus griseus [Animal]

FamilyMonoclonal antibody

Tax ID9606;10090;10029

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Monoclonal antibody Lymphocyte-depleting antibody

Half-Life288 h

PaperPubMed-linked source references: PMID:27645339; PMID:26384035; PMID:26253589; PMID:25887773; PMID:25846320; PMID:24090587; PMID:19967103; PMID:16810345; PMID:16179960 PMID27645339;26384035;26253589;25887773;25846320;24090587;19967103;16810345;16179960 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27645339/ PatentCA1339198