Peptide Database

Peptide Nameisunakinra

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Signaling peptide

Other / Curated residual function label ▸ Generic enzyme inhibition annotation

Standard StatusStandard

Sequence Length153 amino acids

Chemical FormulaC796H1240N204O234S9

DescriptionStandard

        APVRSLNCRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWFLCTAMEADQPVSLTNMPDEGVMVTKFYMQFVSS
    

Molecular Weight17700.17 Da

Isoelectric Point (pI)6.58

Net Charge (pH 7.0)-0.21

Net Charge (pH 7.4) -0.50

Charge Density (pH 7.0) -0.0014

GRAVY Index-0.45

Hydrophobic Moment 0.51

Boman Index-0.04

Instability Index53.22

Aliphatic Index 76.99

Aromaticity 0.1111

Extinction Coeff. Reduced 18450.00

Extinction Coeff. Oxidized 18575.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7138.17

LogP -63.86

H-bond Donors 238.0

H-bond Acceptors 243.0

Rotatable Bonds 595.0

Heavy Atoms 1243.0

Ring Count 28.0

Amide Bonds 174.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0019968 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGtoPdb peptide ligand

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Enzyme inhibitory Immunomodulatory Signaling peptide

TargetInterleukin-1 receptor, type I (Human)

Activity0.03 nM

MethodKd