Peptide Database

Peptide NameSafencin (48-70)[G2W;E4,13K]

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC144H243N43O30

DescriptionStandard

        AWKKTIRQYLKNKIKKKGRKAVIAW
    

Molecular Weight3056.74 Da

Isoelectric Point (pI)11.36

Net Charge (pH 7.0)9.79

Net Charge (pH 7.4) 9.59

Charge Density (pH 7.0) 0.3915

GRAVY Index-0.98

Hydrophobic Moment 0.70

Boman Index-0.33

Instability Index10.18

Aliphatic Index 86.00

Aromaticity 0.1200

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1251.90

LogP -6.96

H-bond Donors 46.0

H-bond Acceptors 40.0

Rotatable Bonds 110.0

Heavy Atoms 217.0

Ring Count 5.0

Amide Bonds 26.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0366489 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetStreptococcus pyogenes GAS M1T1

Activity8 μM

MethodMIC

RECORD: Rec_0402285 VERIFIED: YES