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MYP_059453
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Basic Information
Tyrocidine A1(K-FF)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
10 amino acids
C67H91N13O14
Standard
Sequence
VKLFPFFNQY
Physicochemical Analysis
1302.52 Da
8.56
0.73
0.52
0.0732
0.26
0.40
0.30
21.07
68.00
0.4000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
448.86
-0.08
14.0
15.0
38.0
94.0
5.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0044259 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Peptide antibiotic
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum 3D7
0.0044 μM
IC50; PLDH assay
PMID17462586 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17462586/
RECORD: Rec_0064464 VERIFIED: YES
Provenance & Taxonomy
Bacillus aneurinolyticus,Bacillus brevis [Bacterium]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
f=D-Phe
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID17462586 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17462586/
RECORD: Rec_0065897 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiparasitic Antimicrobial Antiplasmodial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0078726 VERIFIED: YES
Provenance & Taxonomy
Bacillus aneurinolyticus,Bacillus brevis [Bacterium]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
f=D-Phe
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes
4
Hemolysis
PMID17462586 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17462586/
RECORD: Rec_0085225 VERIFIED: YES
Provenance & Taxonomy
Bacillus aneurinolyticus,Bacillus brevis [Bacterium]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
f=D-Phe
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
12 μM
LC50
PMID17462586 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17462586/
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