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MYP_059424
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Basic Information
Viba 15
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C116H185N35O39S6
Standard
Sequence
GLPVCGETCVGGTCNTPGCACSWPVCTRN
Physicochemical Analysis
2886.31 Da
5.96
-0.30
-0.59
-0.0102
0.24
0.24
0.17
50.50
46.90
0.0345
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1154.07
-17.62
45.0
45.0
83.0
196.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0104365 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Non-Cancer cell line: HFF-1
2.38±0.09 μM
IC50
PaperPubMed PMID: 21723349 PMID21723349 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21723349/
RECORD: Rec_0121769 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Cancer cell lines: BGC-823
1.32±0.15 μM
IC50
PaperPubMed PMID: 21723349 PMID21723349 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21723349/
RECORD: Rec_0134468 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]; Viola baoshanensis [Plant]; Viola philippica [Plant]
Cyclotide
214053, 349688, 39648
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Antimicrobial
Human skin melanomaMM96L
3.10±0.06 μM
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola philippica | PubMed PMID 25815330 PMID25815330;21723349 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25815330/
RECORD: Rec_0159145 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]; Viola baoshanensis [Plant]; Viola philippica [Plant]
Cyclotide
214053, 349688, 39648
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Antimicrobial
Human cervical carcinoma HeLa
10.21±0.43 μM
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola philippica | PubMed PMID 25815330 PMID25815330;21723349 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25815330/
RECORD: Rec_0185808 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide; DSSP H 0.0%, E 6.9%, T 48.3%, C 44.8% [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Toxic Antimicrobial Cytotoxic
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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