Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length503 amino acids

Chemical FormulaC2485H3986N668O683S15

DescriptionStandard

        MATRRLALAASVLAICMVLTRATNPGFVARITAKGLDYARQEGIAALQKELAKLKLPDFSGTFKVKLLGKVHYTFSSLNLRSFQLPSSQIAPIPNVGLKVSITNAFAQLTGKWRVKKRFVRDSGSFDLKVEGLSISIGLKLGSDASGRPTVTTSECGTHISNVRVHISGRFGWLYNLFHKKIESTFRRTMEGKVCGAVTSSVTTKLQPYLQTVPVTAKIDKVAGIDYSLVAPPAATAQSLDMNLKGEFFSLAHRSAVPFPPPALAFPVDHDRMVYCGASSYFFNTAGFVYHTAGALLFEITDAMIPKEFKFHLNTSTFSAFIPQLEKMYPDKLMKLRIKTSSAPFLTITPGNLSLTPVVDIQAYVILPNSSLVPVFLLSVTSSVSAKLMVTAARIGGTLELGRLQLSLKHSDVGPFSVQLLQALINFYGSSILIPRVNARLKEGFPLPLPAGVQLSNLVIQPRQVSEHSPLCWAKGPLGNNLGQQIMPAAGRIRVRSSLPSRV
    

Molecular Weight54629.27 Da

Isoelectric Point (pI)10.11

Net Charge (pH 7.0)29.33

Net Charge (pH 7.4) 28.45

Charge Density (pH 7.0) 0.0583

GRAVY Index0.17

Hydrophobic Moment 0.74

Boman Index0.13

Instability Index40.83

Aliphatic Index 100.04

Aromaticity 0.0835

Extinction Coeff. Reduced 32890.00

Extinction Coeff. Oxidized 33140.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0023888 VERIFIED: NO

Provenance & Taxonomy

OrganismPlatysternon megacephalum [Bacterium]

FamilyBPI

Tax ID55544

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence