Peptide Database

Peptide NameOsteocrin

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length50 amino acids

Chemical FormulaC237H392N84O70S

DescriptionStandard

        SFSGFGSPLDRLSAGSVEHRGKQRKAVDHSKKRFGIPMDRIGRNRLSSSR
    

Molecular Weight5570.23 Da

Isoelectric Point (pI)11.79

Net Charge (pH 7.0)7.64

Net Charge (pH 7.4) 7.32

Charge Density (pH 7.0) 0.1527

GRAVY Index-0.98

Hydrophobic Moment 0.73

Boman Index-0.34

Instability Index29.15

Aliphatic Index 54.60

Aromaticity 0.0600

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2545.73

LogP -34.07

H-bond Donors 94.0

H-bond Acceptors 81.0

Rotatable Bonds 193.0

Heavy Atoms 392.0

Ring Count 7.0

Amide Bonds 51.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0032682 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyOsteocrin

Tax ID10090

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone Endocrine Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0096914 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyOsteocrin

Tax ID10090

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone Endocrine Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory

Targetnatriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (PubMed:14523025, PubMed:17951249)

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0418957 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyOsteocrin

Tax ID10090

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone Endocrine Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory

Targetskeletal muscle

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour