Peptide Database

Peptide NameSLAY-screened peptide P846

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC94H137N27O22S

DescriptionStandard

        HITRCAPDWAYVLLHPH
    

Molecular Weight2029.33 Da

Isoelectric Point (pI)7.01

Net Charge (pH 7.0)0.01

Net Charge (pH 7.4) -0.36

Charge Density (pH 7.0) 0.0007

GRAVY Index-0.08

Hydrophobic Moment 0.54

Boman Index0.16

Instability Index31.62

Aliphatic Index 97.65

Aromaticity 0.1176

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 752.83

LogP -3.38

H-bond Donors 27.0

H-bond Acceptors 26.0

Rotatable Bonds 56.0

Heavy Atoms 144.0

Ring Count 8.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0068852 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/