Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2334H3778N606O656S20

DescriptionStandard

        MVLCCWLALVALIPMTLSINPGVKVRLTGKGLEYGRQLGMASIQQKLKTIKVPDISGKQRVSPIGKVKYSLSNMQIVDVGLPKSALDLVPGTGVKLSIGNAFLRMHGNWRVKYLRIIKDSGSFDLNVNDLTITTTIAIKSDETGRPVVSSVNCAATVGSAKIKFHGGASWLYNLFRKFVDKAIRNALQKQMCPLVANAVSDLNPQLKTLNVLAKVDQYAEIEYSMVSSPTVSNSCIDFSLKGEFYNIGKHQEPPFSPAAFSLPPQINNMLYISVSAFTINSAAFVYNTAGALSLYITDDMIPQASPIRLNTRTFGAFIPQVAKRFPGLMMKLLVKTAKNPVVTFEPNKVTVQATSTVTAYAIQPNTTLSPLFVLNLETSVSARVFVSGMRLAGAVTLNKMALTLGTSYVGEFQVRSLDSIFQVVLKVVVIPILNVQLAKGYPLPTLGKMKLVNTELQVLKDYMLIGTDVQFTG
    

Molecular Weight51465.93 Da

Isoelectric Point (pI)9.74

Net Charge (pH 7.0)21.71

Net Charge (pH 7.4) 21.17

Charge Density (pH 7.0) 0.0459

GRAVY Index0.25

Hydrophobic Moment 0.84

Boman Index0.16

Instability Index29.12

Aliphatic Index 105.88

Aromaticity 0.0782

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37610.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0198589 VERIFIED: YES

Provenance & Taxonomy

OrganismSebastes schlegelii [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria