‹ ›
MYP_059260
← PREVIOUS NEXT → BACK
Basic Information
Dermaseptin-3
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
30 amino acids
C138H240N38O35S
Standard
Sequence
ALWKNMLKGIGKLAGKAALGAVKKLVGAES
Physicochemical Analysis
3023.68 Da
10.30
4.79
4.59
0.1598
0.35
0.70
0.19
-5.28
117.33
0.0333
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1179.75
-8.69
41.0
41.0
108.0
212.0
2.0
30.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0375825 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 66.7%, E 0.0%, T 20.0%, C 13.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antiviral Antiparasitic Toxic Antimicrobial Antifungal Antiplasmodial Hemolytic Anti-Gram-positive Anti-Gram-negative
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0377963 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0383404 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
0.8 μM
MIC
PaperJ.K. Ghosh et al. / JBC 272 (1997) 31609-31616. Selective Cytotoxicity of Dermaseptin S3 toward IntraerythrocyticPlasmodium falciparum and the Underlying Molecular Basis Evidence URLhttps://www.uniprot.org/uniprotkb/P80279/entry
RECORD: Rec_0385666 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagei [Animal]
Dermaseptin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiprotozoal
PaperPubMed PMID: 8306981 | PubMed PMID: 9395500 PMID8306981;9395500 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8306981/
RECORD: Rec_0392738 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
50.0 μM
HC50
PaperJ.K. Ghosh et al. / JBC 272 (1997) 31609-31616. Selective Cytotoxicity of Dermaseptin S3 toward IntraerythrocyticPlasmodium falciparum and the Underlying Molecular Basis Evidence URLhttps://www.uniprot.org/uniprotkb/P80279/entry
FIRST PREV 1 ... 5 6 7 8 NEXT LAST
Showing 5 records on this page · Page 7 of 8