MYP_059130
P21L2
Antimicrobial
Antiviral
▸
Antiviral mechanism
▸
Membrane / Ion-channel modulation
▸
Sodium channel modulation
▸
Sodium channel inhibitor
not Standard
21 amino acids
-
contains X representing unresolved or non-standard residue
LXLTYXMLSLQQVVKALNESY
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Amino Acid Composition
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0383118
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
①The 'X' (position: 2 and 6) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. ②X (2) and X (6) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0414868
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at position 2 and 6 are S5((S)-pentenyl alanine)
Bio-Activity Profile
Antimicrobial
MERS-CoV:inhibition of cell-cell fusion in Huh-7 cells
10.9±1.1 μM
EC50
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