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MYP_059130
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Basic Information
P21L2
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
not Standard
21 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
LXLTYXMLSLQQVVKALNESY
Physicochemical Analysis
0.00 Da
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001792 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 2 and 6 are S5((S)-pentenyl alanine)
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibition
MERS-CoV | Huh-7 cells
10.9±1.1 μM
EC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperDiscovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors. | Wang C, Xia S, Zhang P, Zhang T, Wang W, Tian Y, Meng G, Jiang S, Liu K. | J Med Chem. 2018 Mar 8;61(5):2018-2026. | DOI:10.1021/acs.jmedchem.7b01732 | PMID:29442512 PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0155601 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
①The 'X' (position: 2 and 6) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. ②X (2) and X (6) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial Antiviral
MERS-CoV:inhibition of cell-cell fusion in Huh-7 cells
3.9±1.1 μM
EC50
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0192055 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 2,6
Bio-Activity Profile
Antiviral
MERS-CoV
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0216627 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
cyclic peptide architecture [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
①The 'X' (position: 2 and 6) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. ②X (2) and X (6) are cross-linked by hydrocarbon stapling.
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibition
MERS-CoV | Huh-7 cells
3.9±1.1 μM
EC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperDiscovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors. | Wang C, Xia S, Zhang P, Zhang T, Wang W, Tian Y, Meng G, Jiang S, Liu K. | J Med Chem. 2018 Mar 8;61(5):2018-2026. | DOI:10.1021/acs.jmedchem.7b01732 | PMID:29442512 PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0244576 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at position 2 and 6 are S5((S)-pentenyl alanine)
Bio-Activity Profile
Antimicrobial Antiviral
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
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