‹ ›
MYP_059076
← PREVIOUS NEXT → BACK
Basic Information
FPWG (L)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Standard
6 amino acids
C33H41N7O7S2
Standard
Sequence
CFPWGC
Physicochemical Analysis
711.85 Da
5.51
-0.26
-0.49
-0.0433
0.82
0.18
0.53
18.35
0.00
0.3333
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
215.82
-0.21
9.0
9.0
16.0
49.0
4.0
5.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0026674 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Library-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Hepatitis C virus (RdRp); Huh7
150 μM
Surface plasmon resonance
PaperIdentification of constrained peptides that bind to and preferentially inhibit the activity of the hepatitis C viral RNA-dependent RNA polymerase. | Amin A, Zaccardi J, Mullen S, Olland S, Orlowski M, Feld B, Labonte P, Mak P. | Virology. 2003 | PMID:12951030 PMID12951030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12951030/
RECORD: Rec_0028007 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Library-derived peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-6
Disulfide-constrained cyclization
Bio-Activity Profile
Antiviral Replication inhibitor
Hepatitis C virus (RdRp); Huh7
50 μM
Surface plasmon resonance
PaperIdentification of constrained peptides that bind to and preferentially inhibit the activity of the hepatitis C viral RNA-dependent RNA polymerase. | Amin A, Zaccardi J, Mullen S, Olland S, Orlowski M, Feld B, Labonte P, Mak P. | Virology. 2003 | PMID:12951030 PMID12951030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12951030/
RECORD: Rec_0086100 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization of a n-terminal Cys residue (forming a disulfide bond)
Cyclization of a C-terminal Cys residue (forming a disulfide bond)
1-6
Disulfide bond between Cys1 and Cys6; Cyclization of a n-terminal Cys residue (forming a disulfide bond); Cyclization of a C-terminal Cys residue (forming a disulfide bond)
Bio-Activity Profile
Antiviral Anti-HCV
Hepatitis C virus(HCV)
50 μM
IC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperIdentification of constrained peptides that bind to and preferentially inhibit the activity of the hepatitis C viral RNA-dependent RNA polymerase. | Amin A, Zaccardi J, Mullen S, Olland S, Orlowski M, Feld B, Labonte P, Mak P. | Virology. 2003 Aug 15;313(1):158-69. | DOI:10.1016/s0042-6822(03)00313-1 | PMID:12951030 PMID12951030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12951030/
RECORD: Rec_0175744 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV
Hepatitis C virus(HCV)
150 μM
IC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperIdentification of constrained peptides that bind to and preferentially inhibit the activity of the hepatitis C viral RNA-dependent RNA polymerase. | Amin A, Zaccardi J, Mullen S, Olland S, Orlowski M, Feld B, Labonte P, Mak P. | Virology. 2003 Aug 15;313(1):158-69. | DOI:10.1016/s0042-6822(03)00313-1 | PMID:12951030 PMID12951030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12951030/
RECORD: Rec_0177665 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 12951030 PMID12951030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12951030/
1 2 NEXT LAST
Showing 5 records on this page · Page 1 of 2