Peptide Database

Peptide NameWNV(1956-1972)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Flavivirus ▸ Anti-Japanese encephalitis virus

Antiviral ▸ Anti-Flavivirus ▸ Anti-West Nile virus

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Helicase inhibition

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC73H128N32O24

DescriptionStandard

        AAQRRGRIGRNPSQVGD
    

Molecular Weight1838.00 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)2.80

Net Charge (pH 7.4) 2.61

Charge Density (pH 7.0) 0.1647

GRAVY Index-1.37

Hydrophobic Moment 0.75

Boman Index-0.50

Instability Index56.91

Aliphatic Index 51.76

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 954.53

LogP -14.78

H-bond Donors 34.0

H-bond Acceptors 27.0

Rotatable Bonds 62.0

Heavy Atoms 129.0

Ring Count 1.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0373941 VERIFIED: YES

Provenance & Taxonomy

OrganismJapanese encephalitis virus [Virus]

FamilyVirus-derived peptide

Tax ID11072;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Replication inhibitor

TargetJapanese encephalitis virus (Replication); Vero

Activity500 μM

MethodHelicase assay

PaperViral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI). | Borowski P, Heising MV, Miranda IB, Liao CL, Choe J, Baier A. | Biochem Pharmacol. 2008 | PMID:18479669 PMID18479669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18479669/

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