Peptide Database

Peptide NameSLAY-screened peptide P5186

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory

Metabolic ▸ Glucose metabolism ▸ Antidiabetic

Standard StatusStandard

Sequence Length2 amino acids

Chemical FormulaC8H14N2O6

DescriptionStandard

TD

Molecular Weight234.21 Da

Isoelectric Point (pI)4.30

Net Charge (pH 7.0)-1.60

Net Charge (pH 7.4) -1.79

Charge Density (pH 7.0) -0.7987

GRAVY Index-2.10

Hydrophobic Moment 0.45

Boman Index-0.47

Instability Index5.00

Aliphatic Index 0.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 149.95

LogP -2.26

H-bond Donors 5.0

H-bond Acceptors 5.0

Rotatable Bonds 6.0

Heavy Atoms 16.0

Ring Count 0.0

Amide Bonds 1.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0085668 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/

RECORD: Rec_0329985 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antidiabetic DPP-IV inhibitory

Targethuman dipeptidyl peptidase IV