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MYP_058907
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Basic Information
peptide 8
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
23 amino acids
C138H243N57O26
Standard
Sequence
IRILQQLLFIHFRIGRRRRRRRR
Physicochemical Analysis
3116.77 Da
12.00
9.85
9.59
0.4281
-0.90
0.55
-0.69
215.67
118.70
0.0870
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1437.38
-11.37
57.0
37.0
111.0
221.0
3.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0155272 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0159020 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Integrase inhibition
inhibition of strand transfer catalyzed by integrase
0.11±0.01 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies. | Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H. | Bioorg Med Chem. 2010 Sep 15;18(18):6771-5. | DOI:10.1016/j.bmc.2010.07.050 | PMID:20708407 PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0245237 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Integrase inhibition
HIV-1
0.26±0.04 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies. | Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H. | Bioorg Med Chem. 2010 Sep 15;18(18):6771-5. | DOI:10.1016/j.bmc.2010.07.050 | PMID:20708407 PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0267899 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of strand transfer catalyzed by integrase
0.11±0.01 μM
IC50
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0396591 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:Inhibition of 3′-processing catalyzed by integrase
0.26±0.04 μM
IC50
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/