Peptide Database

Peptide NameSLAY-screened peptide P3795

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC89H132N20O22S

DescriptionStandard

        NGSFLQQWLPLSLFIC
    

Molecular Weight1866.19 Da

Isoelectric Point (pI)5.52

Net Charge (pH 7.0)-0.25

Net Charge (pH 7.4) -0.47

Charge Density (pH 7.0) -0.0156

GRAVY Index0.80

Hydrophobic Moment 0.31

Boman Index0.43

Instability Index52.14

Aliphatic Index 121.88

Aromaticity 0.1875

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 676.55

LogP -3.43

H-bond Donors 23.0

H-bond Acceptors 23.0

Rotatable Bonds 57.0

Heavy Atoms 132.0

Ring Count 5.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0188980 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/