Peptide Database

Peptide NameBrevinin-1-OR1 (Frogs, amphibians, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length23 amino acids

Chemical FormulaC108H172N28O29S4

DescriptionStandard

        LPFVAGVAAEMMQHVYCAASKKC
    

Molecular Weight2454.95 Da

Isoelectric Point (pI)8.04

Net Charge (pH 7.0)0.83

Net Charge (pH 7.4) 0.54

Charge Density (pH 7.0) 0.0360

GRAVY Index0.65

Hydrophobic Moment 0.40

Boman Index0.27

Instability Index18.50

Aliphatic Index 76.52

Aromaticity 0.0870

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 896.30

LogP -6.78

H-bond Donors 32.0

H-bond Acceptors 35.0

Rotatable Bonds 78.0

Heavy Atoms 169.0

Ring Count 4.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0385584 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana rotodora [Animal]

FamilyBrevinin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide17-23

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetStaphylococcus aureus ATCC 25923

Activity10.6 μg/mL

MethodMIC

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