‹ ›
MYP_058840
← PREVIOUS NEXT → BACK
Basic Information
Esculentin-1SEb
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Adverse immune reactivity ▸ Histamine-release modulation
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
46 amino acids
C224H382N60O60S2
Standard
Sequence
GLFSKFNKKKIKSGLFKIIKTAGKEAGLEALRTGIDVIGCKIKGEC
Physicochemical Analysis
4939.93 Da
9.87
6.74
6.49
0.1465
-0.03
0.67
0.02
5.31
97.61
0.0652
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1968.13
-16.36
71.0
69.0
181.0
346.0
3.0
46.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0169471 VERIFIED: YES
Provenance & Taxonomy
Lithobates sevosus [Animal]
Esculentin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Mast cell degranulation Histamine releasing
PaperC. Graham et al. / Peptides 27 (2006) 1313-1319. Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa Evidence URLhttps://www.uniprot.org/uniprotkb/P85054/entry
RECORD: Rec_0176955 VERIFIED: YES
Provenance & Taxonomy
Rana sevosa [Animal]
Esculentin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus NCT C2665
PaperPubMed PMID: 16386333 PMID16386333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16386333/
RECORD: Rec_0191392 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 52.2%, E 0.0%, T 21.7%, C 26.1% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0220150 VERIFIED: YES
Provenance & Taxonomy
Rana sevosa [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli K12
PMID16386333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16386333/
RECORD: Rec_0359214 VERIFIED: YES
Provenance & Taxonomy
Rana sevosa [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus NCT C2665
PMID16386333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16386333/
FIRST PREV 1 2 3 NEXT LAST
Showing 5 records on this page · Page 2 of 3