Peptide Database

Peptide NameSLAY-screened peptide P5347

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC90H142N28O21S2

DescriptionStandard

        LIRNLCRMTHHYFSPK
    

Molecular Weight2016.40 Da

Isoelectric Point (pI)10.05

Net Charge (pH 7.0)2.92

Net Charge (pH 7.4) 2.60

Charge Density (pH 7.0) 0.1827

GRAVY Index-0.49

Hydrophobic Moment 0.75

Boman Index-0.15

Instability Index70.21

Aliphatic Index 73.12

Aromaticity 0.1250

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 801.99

LogP -5.98

H-bond Donors 30.0

H-bond Acceptors 28.0

Rotatable Bonds 64.0

Heavy Atoms 141.0

Ring Count 5.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0039607 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/