Peptide Database

Peptide NameEK1

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC196H317N43O64S

DescriptionStandard

        SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKEL
    

Molecular Weight4331.93 Da

Isoelectric Point (pI)4.36

Net Charge (pH 7.0)-5.52

Net Charge (pH 7.4) -5.76

Charge Density (pH 7.0) -0.1534

GRAVY Index-0.43

Hydrophobic Moment 0.75

Boman Index-0.05

Instability Index22.73

Aliphatic Index 119.17

Aromaticity 0.0833

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1772.25

LogP -9.98

H-bond Donors 59.0

H-bond Acceptors 60.0

Rotatable Bonds 156.0

Heavy Atoms 304.0

Ring Count 3.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0399290 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Fusion inhibition

TargetSARS-CoV-2; 293T/ACE2 cells; VERO-E6 cells

Activity2.468 μM

MethodIC50

Half-LifeMammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h

PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. | Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L. | Cell Res. 2020 Apr;30(4):343-355. | DOI:10.1038/s41422-020-0305-x | PMID:32231345 PMID32231345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32231345/

RECORD: Rec_0400090 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

TargetSARS-CoV-2 D614G

Activity0.3146 μM

MethodIC50

PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 2020 Apr;30(4):343-355. doi: 10.1038/s41422-020-0305-x. PMID: 32231345 PMID35087243;32231345;30989115;32047258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35087243/

RECORD: Rec_0402529 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

TargetSARS-CoV-2 Delta

Activity0.1318 μM

MethodIC50

PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 2020 Apr;30(4):343-355. doi: 10.1038/s41422-020-0305-x. PMID: 32231345 PMID35087243;32231345;30989115;32047258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35087243/

RECORD: Rec_0404572 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

TargetHCoV-NL63; Huh-7 cells

Activity0.751 μM

MethodIC50

PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 2020 Apr;30(4):343-355. doi: 10.1038/s41422-020-0305-x. PMID: 32231345 PMID35087243;32231345;30989115;32047258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35087243/

RECORD: Rec_0414553 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermPEG8-K(Chol)

Other ModsPEG8-K(Chol)

Bio-Activity Profile

Function

Antiviral Anti-HCoV-229E Fusion inhibition

TargetHCoV-229E; Huh-7 cells

Activity0.5033±0.0209 μM

MethodIC50

Half-LifeMammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h

PaperSARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. | Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y. | Signal Transduct Target Ther. 2021 Aug 3;6(1):294. | DOI:10.1038/s41392-021-00698-x | PMID:34344868 PMID34344868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34344868/

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