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MYP_058737
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Basic Information
EK1
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Standard
36 amino acids
C196H317N43O64S
Standard
Sequence
SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKEL
Physicochemical Analysis
4331.93 Da
4.36
-5.52
-5.76
-0.1534
-0.43
0.75
-0.05
22.73
119.17
0.0833
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1772.25
-9.98
59.0
60.0
156.0
304.0
3.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0146313 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
PEG4-C(Chol)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells
0.1394 μM
IC50
PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion PMID32231345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32231345/
RECORD: Rec_0152210 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
CoV-SHC014:inhibition of cell-cell fusion in Huh-7 cells
0.2796 μM
IC50
PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 2020 Apr;30(4):343-355. doi: 10.1038/s41422-020-0305-x. PMID: 32231345 PMID35087243;32231345;30989115;32047258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35087243/
RECORD: Rec_0156795 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
inhibition of infection(Authentic)
1.138 μM
IC50
PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 2020 Apr;30(4):343-355. doi: 10.1038/s41422-020-0305-x. PMID: 32231345 PMID35087243;32231345;30989115;32047258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35087243/
RECORD: Rec_0158464 VERIFIED: YES
Provenance & Taxonomy
Human coronavirus OC43 [Virus]
HR2-derived fusion inhibitor
31631
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Human coronavirus 229E
0.20 μM
IC50
PaperA pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike PMID30989115 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30989115/
RECORD: Rec_0158646 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
inhibition of Pseudovirus (PsV) infection in Huh-7 cells
6.014 μM
IC50
PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 2020 Apr;30(4):343-355. doi: 10.1038/s41422-020-0305-x. PMID: 32231345 PMID35087243;32231345;30989115;32047258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35087243/
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