Peptide Database

Peptide NamePRW4

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC107H179N39O18

DescriptionStandard

        RFRRLRWKTRWRLKKI
    

Molecular Weight2299.82 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)8.76

Net Charge (pH 7.4) 8.55

Charge Density (pH 7.0) 0.5473

GRAVY Index-1.64

Hydrophobic Moment 0.27

Boman Index-0.84

Instability Index118.20

Aliphatic Index 73.12

Aromaticity 0.1875

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1001.09

LogP -5.15

H-bond Donors 41.0

H-bond Acceptors 27.0

Rotatable Bonds 80.0

Heavy Atoms 164.0

Ring Count 5.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0279506 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetEnterococcus faecalis 29212

Activity4 μM

MethodMIC

RECORD: Rec_0282458 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetPseudomonas aeruginosa 10419

Activity36.8 μg/mL

MethodMIC

PaperCharacterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of α-helix-based peptide amphiphiles. Biomaterials. 2015 Jun;52:517-30. doi: 10.1016/j.biomaterials.2015.02.063. PMID: 25818457. PMID25818457 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25818457/

RECORD: Rec_0304527 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hemolytic

Targethuman red blood cells

Activity294.3 μg/mL

MethodHemolysis

RECORD: Rec_0312390 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

TargetStaphylococcus epidermidis 12228

Activity8 μM

MethodMIC

RECORD: Rec_0317235 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus 25923

Activity73.6 μg/mL

MethodMIC

PaperCharacterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of α-helix-based peptide amphiphiles. Biomaterials. 2015 Jun;52:517-30. doi: 10.1016/j.biomaterials.2015.02.063. PMID: 25818457. PMID25818457 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25818457/

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