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MYP_058644
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Basic Information
PRW4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
16 amino acids
C107H179N39O18
Standard
Sequence
RFRRLRWKTRWRLKKI
Physicochemical Analysis
2299.82 Da
12.00
8.76
8.55
0.5473
-1.64
0.27
-0.84
118.20
73.12
0.1875
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1001.09
-5.15
41.0
27.0
80.0
164.0
5.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0211602 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
human red blood cells
256 μM
MHC
PMID25735802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25735802/
RECORD: Rec_0234046 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus 29213
8 μM
MIC
PMID25735802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25735802/
RECORD: Rec_0238360 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis 12228
16 μM
MIC
PMID25735802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25735802/
RECORD: Rec_0246814 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus 29213
8 μM
MIC
PMID25735802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25735802/
RECORD: Rec_0247263 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ER2566
18.4 μg/mL
MIC
PaperCharacterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of α-helix-based peptide amphiphiles. Biomaterials. 2015 Jun;52:517-30. doi: 10.1016/j.biomaterials.2015.02.063. PMID: 25818457. PMID25818457 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25818457/
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