Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2367H3744N596O676S19

DescriptionStandard

        MKMASAFCLVLLLFPSLCFTRNPGIKGKMSTKGLQYVSKVVIDLLSKKARQVQIPDFSGSTDLGIISINYDITRLHIDSLKMPSPDVEFSPNTDIKVRIVNARLQASGDWQVKYLFISDSGTFTAGVYGITIKLNIGVTADDTGRLMVWNSYCLGQVGSVDIQLHGGGSWFYGLFHSKLQDIALQQINQKLCSSVHTAFTAVNQQLKKIPGFVSIDQYIELDYLLVSLPEVTEKFLGTDFKGEFYNIKHHTEPPFEPTPFYLCCQDGYMFSLGVSQYSVNSAAYAYYTAGALQIQVTDNMIPKASPIRLNTSSFGNFIPGLSKLYPNMLMVMEVNANKQPLVTLGMGSITTETSFSLNTFAILPNTSLARVFVLELSVSVSGKVQLSGMKLTGLIVLNNISLSVAHSDIGPFDVKPIEKLVKIAAYTLGISTINARLKKGFPLPHTDKLKFINPLLKMNQGVITVATDVQINL
    

Molecular Weight51975.87 Da

Isoelectric Point (pI)8.88

Net Charge (pH 7.0)7.15

Net Charge (pH 7.4) 6.33

Charge Density (pH 7.0) 0.0151

GRAVY Index0.18

Hydrophobic Moment 0.70

Boman Index0.17

Instability Index31.15

Aliphatic Index 102.79

Aromaticity 0.0951

Extinction Coeff. Reduced 41830.00

Extinction Coeff. Oxidized 42205.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0200710 VERIFIED: NO

Provenance & Taxonomy

OrganismLatimeria chalumnae [Animal]

FamilyBPI/LBP

Tax ID7897

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria