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MYP_058492
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Basic Information
Neutrophil defensin 3 (Defensin; alpha 3) (HNP-3) (HP-3) (HP3) [Cleaved into: HP 3-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
94 amino acids
C451H723N127O129S8
Standard
Sequence
MRTLAILAAILLVALQAQAEPLQARADEVAAAPEQIAADIPEVVVSLAWDESLAPKHPGSRKNMDCYCRIPACIAGERRYGTCIYQGRLWAFCC
Physicochemical Analysis
10244.86 Da
5.71
-1.46
-1.83
-0.0155
0.23
0.58
0.11
43.72
100.96
0.0638
15470.00
15845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
4055.86
-34.86
145.0
137.0
328.0
715.0
15.0
99.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009941 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Alpha-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antifungal Antiviral Anti-HSV Anti-Gram-positive Cytotoxic Non-hemolytic
Staphylococcus aureus (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID3174637;2918759;8477861;8325384;15489334;4056036;2917986;1339298;15616305;15772169;17142766;18435932;25963798;29282039;2006422;15894545;17452329 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3174637/
RECORD: Rec_0212998 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Alpha-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antifungal Antiviral Anti-HSV Anti-Gram-positive Cytotoxic Non-hemolytic
Clostridium difficile (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID3174637;2918759;8477861;8325384;15489334;4056036;2917986;1339298;15616305;15772169;17142766;18435932;25963798;29282039;2006422;15894545;17452329 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3174637/
RECORD: Rec_0225390 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ7188
RECORD: Rec_0257446 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperNeutrophil defensin 3 (Defensin, alpha 3), (HNP-3), (HP-3), (HP3) Evidence URLhttps://www.uniprot.org/uniprotkb/P59666/entry
RECORD: Rec_0407323 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Defensin Antifungal Fungicide Non-hemolytic Non-ribosomal
Qualitative functional evidence
PMID15489334 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15489334/; https://www.uniprot.org/uniprotkb/Q6EZE9/entry; https://bblserver.org.in/ampdb/