Peptide Database

Peptide NameCytotoxic linear peptide IsCT2 (Non-disulfide-bridged peptide 4.2) (NDBP-4.2) (Non-disulfide-bridged peptide 5.3) (NDBP-5.3) [Cleaved into: Cytotoxic linear peptide IsCT2f]

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length71 amino acids

Chemical FormulaC366H573N91O105S3

DescriptionStandard

        MKTQFAILLVALVLFQMFAQSEAIFGAIWNGIKSLFGRRALNNDLDLDGLDELFDGEISQADVDFLKELMR
    

Molecular Weight8024.21 Da

Isoelectric Point (pI)4.30

Net Charge (pH 7.0)-5.48

Net Charge (pH 7.4) -5.72

Charge Density (pH 7.0) -0.0772

GRAVY Index0.34

Hydrophobic Moment 0.57

Boman Index0.18

Instability Index22.92

Aliphatic Index 115.49

Aromaticity 0.1127

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3172.72

LogP -21.93

H-bond Donors 107.0

H-bond Acceptors 103.0

Rotatable Bonds 275.0

Heavy Atoms 565.0

Ring Count 9.0

Amide Bonds 77.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0328157 VERIFIED: YES

Provenance & Taxonomy

OrganismOpisthacanthus madagascariensis [Animal]

FamilyNDBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Cytolytic Toxin Hemolytic

TargetGram Negative Bacteria and Gram Positive Bacteria