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MYP_058341
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Basic Information
DRS S9
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
24 amino acids
C145H228N36O31S2
Standard
Sequence
GLRSKIWLWVLLMIWQESNKFKKM
Physicochemical Analysis
3035.71 Da
10.46
3.76
3.55
0.1566
-0.01
0.49
0.09
77.09
109.58
0.1667
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1109.91
-2.20
40.0
37.0
104.0
214.0
7.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0341060 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagei [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID16401077 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16401077/
RECORD: Rec_0363614 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 IIIB | CEM-SS cells
31.6 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. | Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. | DOI:10.1128/AAC.01448-09 | PMID:20086159 PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
RECORD: Rec_0373861 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
3.1 μM
MIC
PaperO. Lequin et al. / Biochemistry 45 (2006) 468-480. Dermaseptin S9, an ?-Helical Antimicrobial Peptide with a Hydrophobic Core and Cationic Termini Evidence URLhttps://www.uniprot.org/uniprotkb/Q1EN15/entry
RECORD: Rec_0396184 VERIFIED: NO
Provenance & Taxonomy
America hylid [Animal]
Dermaseptin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0404042 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
175.0 μM
HC50
PaperO. Lequin et al. / Biochemistry 45 (2006) 468-480. Dermaseptin S9, an ?-Helical Antimicrobial Peptide with a Hydrophobic Core and Cationic Termini Evidence URLhttps://www.uniprot.org/uniprotkb/Q1EN15/entry
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