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MYP_058334
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Basic Information
[P5K,D9K]Hymenochirin-1B
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
29 amino acids
C142H263N39O35S
Standard
Sequence
IKLSKETKKNLKKVLKGAIKGAIAVAKMV
Physicochemical Analysis
3108.91 Da
10.54
7.75
7.54
0.2674
0.08
0.69
-0.02
-8.38
124.48
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1233.15
-8.41
43.0
44.0
118.0
217.0
0.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0004039 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Klebsiella pneumoniae
6.25 μM
MIC
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties. Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. PMID: 24172540 PMID24172540;30789695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
RECORD: Rec_0013205 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Candida albicans ATCC 90028
50 μM
MIC
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties. Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. PMID: 24172540 PMID24172540;30789695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
RECORD: Rec_0015290 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Hymenochirin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 6 and 10) in sequence indicate (S)-N-Fmoc-2-(4'-pentenyl)alanine. Ⓧ (6) and Ⓧ (10) are cross-linked by ring-closing metathesis through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Anticancer
HCT116
1.49±0.45 μM
IC50
PaperYulei Li, Yihan Zhang, Minghao Wu, Qi Chang, Honggang Hu, Xia Zhao. Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy. ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1. PMID30789695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30789695/
RECORD: Rec_0023031 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Staphylococcus epidermidis RP62A/1
1.6 μM
MIC
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties. Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. PMID: 24172540 PMID24172540;30789695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
RECORD: Rec_0029347 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Hymenochirin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 6, 10, 18 and 22) in sequence indicate (S)-N-Fmoc-2-(4'-pentenyl)alanine. Ⓧ (6) and Ⓧ (10), Ⓧ (18) and Ⓧ (22) are cross-linked by ring-closing metathesis through an oct-4-enyl hydrocarbon staple, respectively
Bio-Activity Profile
Anticancer
HepG2
1.50±0.28 μM
IC50
PaperYulei Li, Yihan Zhang, Minghao Wu, Qi Chang, Honggang Hu, Xia Zhao. Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy. ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1. PMID30789695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30789695/
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