Peptide Database

Peptide NameProkineticin Bo8

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length77 amino acids

Chemical FormulaC332H533N103O107S10

DescriptionStandard

        AVITGACDRDVQCGSGTCCAASAWSRNIRFCVPLGNSGEECHPASHKVPYDGKRLSSLCPCKSGLTCSKSGAKFQCS
    

Molecular Weight8000.06 Da

Isoelectric Point (pI)8.60

Net Charge (pH 7.0)3.87

Net Charge (pH 7.4) 3.42

Charge Density (pH 7.0) 0.0503

GRAVY Index-0.18

Hydrophobic Moment 0.59

Boman Index-0.02

Instability Index50.99

Aliphatic Index 54.55

Aromaticity 0.0519

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3352.92

LogP -48.06

H-bond Donors 128.0

H-bond Acceptors 123.0

Rotatable Bonds 259.0

Heavy Atoms 552.0

Ring Count 11.0

Amide Bonds 80.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0165144 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina orientalis [Animal]

FamilyProkineticin Bo8

Tax ID8346

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-76

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory

TargetDRG neurons

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0304361 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina orientalis [Animal]

FamilyProkineticin Bo8

Tax ID8346

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-76

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory

Targetguinea-pig gastrointestinal (GI) smooth muscle

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0364531 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina orientalis [Animal]

FamilyProkineticin Bo8

Tax ID8346

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-76

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour