Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length453 amino acids

Chemical FormulaC2209H3577N577O639S18

DescriptionStandard

        MFLLKCLPLVALIAAAFSANPGVKIRLTQKGLEYGRQLGVASLLEKLKTAQIPDFSGKERVSPIGKVQYSLTNIHIVNLGLPQSSINLVPGSGVQLSISNAFINLRGNWRVKYLRIIKDSGSLDVNVNGLSISQTIAIKSDATGKPEASSAACSASVSSAKVKFHGGASWLYNLFSKFIDKALRKALEKQMCPLVAKSIADLNPRLKTLNVLAKVDKYAEIEYSMVSSPQISQPAIDLNLKGEFYNIGRHQEAPFPAPAFSLPAQSSNMIYIALSSFTPNSAGFVYNNAGVLSMYVTDDMIAQRFPNLMMKMLVKADKNPVVKFQPNVMTVDATATATAYAIQPNGTLSPLFVLNVDSSVSSQMSVSDLKLASRITLNKMSLSLGTSYVGDFKVNSLDNILQVILKLVVIPTVNVQLSKGYPLPALGKMKLVNTQLQIMQDYLMIGTDVQFTG
    

Molecular Weight49019.68 Da

Isoelectric Point (pI)9.61

Net Charge (pH 7.0)16.73

Net Charge (pH 7.4) 16.22

Charge Density (pH 7.0) 0.0369

GRAVY Index0.17

Hydrophobic Moment 0.85

Boman Index0.14

Instability Index37.21

Aliphatic Index 105.25

Aromaticity 0.0728

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 31985.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0400597 VERIFIED: NO

Provenance & Taxonomy

OrganismOryzias sinensis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence