Peptide Database

Peptide NameSLAY-screened peptide P5015

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC84H123N29O30S2

DescriptionStandard

        QCQYCHTNTENHQSAYR
    

Molecular Weight2083.18 Da

Isoelectric Point (pI)6.90

Net Charge (pH 7.0)-0.08

Net Charge (pH 7.4) -0.42

Charge Density (pH 7.0) -0.0050

GRAVY Index-1.76

Hydrophobic Moment 0.29

Boman Index-0.40

Instability Index24.24

Aliphatic Index 5.88

Aromaticity 0.1176

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1002.08

LogP -14.71

H-bond Donors 36.0

H-bond Acceptors 34.0

Rotatable Bonds 66.0

Heavy Atoms 145.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0143193 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/