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MYP_058165
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Basic Information
RGD-La
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C90H154N26O22
Standard
Sequence
RGDLLRHVVKILEKYL
Physicochemical Analysis
1952.35 Da
9.70
1.85
1.59
0.1155
-0.04
0.82
-0.10
33.08
158.12
0.0625
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
799.17
-3.12
29.0
25.0
68.0
138.0
2.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0369037 VERIFIED: YES
Provenance & Taxonomy
Arg-Gly-Asp [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
rabbit erythrocytes and human erythrocytes at 250 μg/ml
PaperPubMed PMID: 22641352 PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/
RECORD: Rec_0407896 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
RGD-modified temporin analogs
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
HeLa (cervical cancer)
50 μg/mL
MTT/MTS assay
PaperDesigned synthetic analogs of the α-helical peptide temporin-La with improved antitumor efficacies via charge modification and incorporation of the integrin αvβ3 homing domain | https://pubmed.ncbi.nlm.nih.gov/22641352/ PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/
RECORD: Rec_0413080 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
RGD-modified temporin analogs
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
MEC (breast cancer)
50 μg/mL
MTT/MTS assay
PaperDesigned synthetic analogs of the α-helical peptide temporin-La with improved antitumor efficacies via charge modification and incorporation of the integrin αvβ3 homing domain | https://pubmed.ncbi.nlm.nih.gov/22641352/ PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/
RECORD: Rec_0415211 VERIFIED: YES
Provenance & Taxonomy
Arg-Gly-Asp [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 22641352 PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/
RECORD: Rec_0423490 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
SMMC-7721
50 μg/mL
Inhibition
PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/
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