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MYP_058153
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Basic Information
Esculentin-2JDa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
37 amino acids
C169H295N45O48S3
Standard
Sequence
GLFTLIKGAAKLIGKTVAKEAGKTGLELMACKITNQC
Physicochemical Analysis
3821.62 Da
9.51
3.74
3.50
0.1011
0.36
0.64
0.17
-1.55
105.68
0.0270
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1508.74
-13.84
54.0
55.0
136.0
265.0
1.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007545 VERIFIED: YES
Provenance & Taxonomy
Odorrana jingdongensis [Animal]
Esculentin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
32 μg/mL
MIC
PMID22917879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22917879/
RECORD: Rec_0021684 VERIFIED: YES
Provenance & Taxonomy
Odorrana jingdongensis [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Extended-spectrum ß-lactamases E
PMID22917879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22917879/
RECORD: Rec_0029750 VERIFIED: YES
Provenance & Taxonomy
Odorrana jingdongensis [Animal]
Esculentin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
No detectable hemolysis at 128 microg/ml
128 μg/mL
Hemolysis
PMID22917879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22917879/
RECORD: Rec_0030129 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Esculentin
167935
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
50.0 μM
MIC
PaperJ.M. Conlon et al. / Peptides 27 (2006) 2111-2117. Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami PMID16621155 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
RECORD: Rec_0034904 VERIFIED: YES
Provenance & Taxonomy
Odorrana jingdongensis [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli (ATCC 25922)
34 μg/mL
MIC
PMID22917879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22917879/
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