Peptide Database

Peptide NameAlpha-toxin Cn12

Function Ontology

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length67 amino acids

Chemical FormulaC303H444N86O100S8

DescriptionStandard

        RDGYPLASNGCKFGCSGLGENNPTCNHVCEKKAGSDYGYCYAWTCYCEHVAEGTVLWGDSGTGPCRS
    

Molecular Weight7147.80 Da

Isoelectric Point (pI)5.46

Net Charge (pH 7.0)-2.14

Net Charge (pH 7.4) -2.58

Charge Density (pH 7.0) -0.0319

GRAVY Index-0.54

Hydrophobic Moment 0.45

Boman Index0.01

Instability Index10.75

Aliphatic Index 36.42

Aromaticity 0.1194

Extinction Coeff. Reduced 18450.00

Extinction Coeff. Oxidized 18950.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2965.03

LogP -38.37

H-bond Donors 111.0

H-bond Acceptors 108.0

Rotatable Bonds 222.0

Heavy Atoms 497.0

Ring Count 15.0

Amide Bonds 70.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0363566 VERIFIED: YES

Provenance & Taxonomy

OrganismCentruroides noxius [Animal]

FamilySodium channel inhibitor family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide11-65; 15-40; 25-45; 29-47

Bio-Activity Profile

Function

Toxin Venom Sodium channel inhibitor family Ion channel inhibitor Host defense