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MYP_058104
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Basic Information
HNP-2
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C147H223N43O37S6
Standard
Sequence
CYCRIPACIAGERRYGTCIYQGRLWAFCC
Physicochemical Analysis
3377.00 Da
8.67
2.70
2.40
0.0931
0.25
0.49
0.05
42.13
64.14
0.1724
9970.00
10345.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1294.03
-10.43
54.0
46.0
103.0
233.0
7.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0209951 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
1-29; 3-18; 8-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-SARS-CoV-2
Enterobacter aerogenes ATCC 13048 (vLD50=16±4.0 μg/ml)
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. | PubMed PMID: 15894545 PMID34206990;15616305;15894545 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0221160 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 8739
PMID15616305 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15616305/
RECORD: Rec_0224835 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
PMID15616305 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15616305/
RECORD: Rec_0249959 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
1-29; 3-18; 8-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-SARS-CoV-2
NOTE: vLD50
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. | PubMed PMID: 15894545 PMID34206990;15616305;15894545 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0278650 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 29213
PMID15616305 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15616305/
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