Peptide Database

Peptide NameT-2635

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC193H305N57O62

DescriptionStandard

        TTWEAWDRAIAEYAARIEALIRAAQEQQEKNEAALREL
    

Molecular Weight4415.83 Da

Isoelectric Point (pI)4.64

Net Charge (pH 7.0)-3.58

Net Charge (pH 7.4) -3.79

Charge Density (pH 7.0) -0.0943

GRAVY Index-0.67

Hydrophobic Moment 0.62

Boman Index-0.15

Instability Index46.93

Aliphatic Index 87.89

Aromaticity 0.0789

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1976.67

LogP -17.65

H-bond Donors 69.0

H-bond Acceptors 59.0

Rotatable Bonds 149.0

Heavy Atoms 312.0

Ring Count 5.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0388404 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antiviral

RECORD: Rec_0390487 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV Fusion inhibition

TargetHIV 098-T20 | CEM4 cells

Activity0.005661 μM

MethodIC50

Half-LifeMammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h

PaperDesign of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus. | Dwyer JJ, Wilson KL, Davison DK, Freel SA, Seedorff JE, Wring SA, Tvermoes NA, Matthews TJ, Greenberg ML, Delmedico MK. | Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12772-7. | DOI:10.1073/pnas.0701478104 | PMID:17640899 PMID17640899 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17640899/

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