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MYP_058043
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Basic Information
T-2635
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
38 amino acids
C193H305N57O62
Standard
Sequence
TTWEAWDRAIAEYAARIEALIRAAQEQQEKNEAALREL
Physicochemical Analysis
4415.83 Da
4.64
-3.58
-3.79
-0.0943
-0.67
0.62
-0.15
46.93
87.89
0.0789
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1976.67
-17.65
69.0
59.0
149.0
312.0
5.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0010804 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral
098-T20 virus
0.025 μg/mL
IC50
Male cynomolgus monkey blood plasma (Intravenous), in vivo; 58680 s
PaperDesign of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus PMID17640899 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17640899/
RECORD: Rec_0023567 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HIV gp41 fusion inhibitor
32630.0
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antiviral Anti-HIV
HIV-1 IIIB
0.10 μg/mL
IC50
PaperDetailed mechanistic insights into HIV-1 sensitivity to three generations of fusion inhibitors; Patent: Novel Methods of Synthesis for Therapeutic Antiviral Peptides PMID19617355 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19617355/ PatentUS 20100261876 A1
RECORD: Rec_0029814 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 098
PMID17640899 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17640899/
RECORD: Rec_0093837 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 098-T1249
PMID17640899 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17640899/
RECORD: Rec_0094022 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral
098-T1249 virus
0.015 μg/mL
IC50
Male cynomolgus monkey blood plasma (Intravenous), in vivo; 58680 s
PaperDesign of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus PMID17640899 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17640899/
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