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MYP_058038
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Basic Information
EKL0P
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
49 amino acids
C269H415N59O84S
Standard
Sequence
SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGTYEYYVKWGSGK
Physicochemical Analysis
5851.58 Da
4.61
-4.53
-4.77
-0.0924
-0.62
0.75
-0.03
14.16
93.47
0.1429
12950.00
12950.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2356.83
-14.06
81.0
81.0
204.0
413.0
8.0
50.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0073282 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Palm
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Inhibition of Pseudovirus(PsV) infection in Caco-2 cells
0.176±0.019 μM
IC50
PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/
RECORD: Rec_0172026 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Palm
Palm
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Fusion inhibition
SARS-CoV-2 | 293T/ACE2 cells
0.619±0.341 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. | Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q. | Acta Pharm Sin B. 2021 Aug 2. | DOI:10.1016/j.apsb.2021.07.026 | PMID:34367893 PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/
RECORD: Rec_0193761 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Palm
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Inhibition of Pseudovirus(PsV) infection in 293T/ACE2 cells
0.619±0.341 μM
IC50
PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/
RECORD: Rec_0217533 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Palm
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus:SARS-CoV-2:Inhibition of Pseudovirus(PsV) infection in Huh-7 cells
0.093±0.012 μM
IC50
PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/
RECORD: Rec_0221242 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Palm
Palm
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Fusion inhibition
SARS-CoV-2 | Huh-7 cells
0.093±0.012 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. | Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q. | Acta Pharm Sin B. 2021 Aug 2. | DOI:10.1016/j.apsb.2021.07.026 | PMID:34367893 PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/
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